Abstract:-
The synthesis of a series of bipyrazoles substituted with benzenesulfonamide, N 1 ,N3 -disubstituted sulfonylurea, sulfonylthiourea pharmacophores, and some derived thiazolidinone and thiazoline ring were prepared as Anticancer and Antidiabetic agents. The key intermediate bipyrazoles were prepared by cyclocondensation of the appropriate chalcone with 4-hydrazinobenzenesulfonamide hydrochloride. The chemistry of the reactions employed in the synthesis of the target compounds together with their chemical behavior, are discussed. Preliminary biological screening of the prepared compounds revealed significant antidiabetic and antibacterial activities