MBS Research Publication
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SYNTHESIS AND BIOLOGICAL EVALUATION OF SOME BIS-PYRAZOLE DERIVATIVES AS ANTICANCER AGENTS

Abdulgader A. Baoum, Reem S.Alsulami , Hassan M. Faidallah* Department of Chemistry, Faculty of Science, King Abdulaziz University, Jeddah, Saudi Arabia

Abstract:-

Cyclocondensation of chalcones 1a-f with the appropriate hydrazine afforded the corresponding 1,4- Bis(1,3-disubstituted-4,5-dihydro-1H-pyrazol-5-yl)benzene. Mild oxidation of these pyrazolines with bromine water yielded the corresponding pyrazoles derivatives. Biological screening of the prepared compounds revealed weak anticancer activity of these derivatives.