Abstract:- Background: Health status of women represents the health status of a country. They form a vulnerable or special risk group. The risk is connected with childbearing and nurturing. Postpartum blues is occurring in 70-80% of postnatal mothers. So the present study was undertaken to assess the knowledge regarding postpartum blues among staff nurses. Methodology: Purposive sampling technique was used to select a sample of 100 staff nurses. Self structured questionnaire was prepared to assess the knowledge regarding postpartum blues among staff nurses. Information booklet was administered after data collection to increase their knowledge.